Primary sclerosing Cholangitis: What you need to know

One in ten thousand people has primary sclerosing (PSC). This condition affects the bile canals between the liver and gallbladder. The liver produces bile that is transported to the gallbladder to be stored or to small intestines to aid in fat digestion. PSC is characterized by inflammation of the bile canals (Cholangitis), which causes scarring and narrowing. The bile is not transported efficiently, which causes it to accumulate in the liver.

PSC does not typically present with symptoms at the beginning, but those who have the condition are more likely to develop autoimmune diseases or cancer. Understanding this condition and its impact on patients can help them become more active in their treatment.

What you need to know about PSC

Primary sclerosing Cholangitis Symptoms

Primary sclerosing Cholangitis symptoms can vary from person to person. Most cases are found during routine tests, as many people have no symptoms. The symptoms that do show up are often vague, such as fatigue, itchiness, or pain in the upper-right quadrant of your abdomen. As the condition advances, symptoms may include a swollen stomach, an enlarged heart, jaundice, and fever.

How long can you expect to live with primary sclerosing Cholangitis (PSC)?

Life expectancy can increase for those who have a liver transplant. Medical professionals advise that individuals with PSC should avoid alcohol, get enough sleep, reduce stress, and develop good exercise habits.

Guidelines for treating primary sclerosing Cholangitis

The focus of PSC treatment is to manage complications and keep a close watch on the disease’s progress. The most common symptom management options are centered around addressing itchy skin.

Bile Acid Sequestrants bind to bile acid, which is responsible for itching

Rifampin is a type of antibiotic that helps relieve itching for those who cannot take sequestrants

Antihistamines can help with itching that is so intense it disturbs sleep

Opioid Antagonists may reduce itching caused by liver disease at the brain level

Ursodeoxycholic Acid (UDCA) is also known as Ursodiol, and it’s a naturally occurring bile acid that can increase the absorption of bile.

PSC patients may also need nutritional support, as it is sometimes difficult for the body to absorb certain vitamins. Doctors often recommend vitamin supplements and a diet rich in nutrients for people with PSC.

Due to the uncertainty surrounding PSC, research is essential for achieving medical advances, and the need for volunteers continues to be paramount. Use the button below to learn more about clinical trials that are currently seeking participants.

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